Edited by: Thomas W. Durso
V.K. Kuchroo, M.P. Das, J.A. Brown, A.M. Ranger, S.S. Zamvil, R.A. Sobel, H.L. Weiner, N. Nabavi, L.H. Glimcher, "B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy," Cell, 80:707-18, 1995. (Cited in nearly 260 publications as of April 1997)

GOOD AND BAD: Harvard's Laurie Glimcher received a surprise after injecting a pair of antibodies into mice suffering from experimental allergic encephalomyelitis
Comments by Laurie H. Glimcher, department of cancer biology, Harvard Medical School

Costimulatory molecules called B7-1 and B7-2 activate a pair of pathways, Th1 and Th2, along which the immune system's T helper (Th) cells mature (G.J. Freeman et al., Journal of Experimental Medicine, 174:625-31, 1991; G.J. Freeman et al., Science, 262:907-9, 1993; G.J. Freeman et al., Science, 262:909-11, 1993). The discovery of B7-1 and B7-2 led to a...

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