Chromatin immunoprecipitation reveals genes regulated by E2A factors during B cell differentiation.
The transcription factors encoded by the
Greenbaum and Zhuang combined an in vivo murine gene-tagging approach with a chromatin immunoprecipitation assay. Mice were generated carrying a dual affinity-tagged
This is the first example of an in vivo murine gene–tagging approach to isolate target genes of an endogenously expressed transcription factor.
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