Barbara Low, Trailblazing Woman in X-Ray Crystallography, Dies

The former Columbia University professor’s early work helped illuminate the structure of penicillin, allowing chemists to make variants and broaden the scope of antibiotic treatments.

Written byCarolyn Wilke
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

Barbara Low, a pioneering scientist who used X-ray crystallography to reveal the shape of molecules including the antibiotic penicillin, died on January 10 at the age of 98, according to a tribute from Columbia University Irving Medical Center.

Low was an emeritus professor of biochemistry and molecular biophysics at Columbia University Vagelos College of Physicians and Surgeons, where she taught for almost 60 years starting in 1956. She retired in 1990, but lectured at Columbia until 2013, according to an obituary in The New York Times.

Low was born in northwestern England in 1920 and earned her bachelor’s degree in chemistry from the University of Oxford’s Sommerville College in 1943, according to the Times. For her graduate studies at Oxford, she worked under the tutelage of Dorothy Hodgkin, a future Nobel laureate. Hodgkin trained Low in X-ray crystallography and during World War II the pair figured out penicillin’s molecular structure.

...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here
Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

fujirebio logo

Products

Eppendorf Logo

Research on rewiring neural circuit in fruit flies wins 2025 Eppendorf & Science Prize

Evident Logo

EVIDENT's New FLUOVIEW FV5000 Redefines the Boundaries of Confocal and Multiphoton Imaging

Evident Logo

EVIDENT Launches Sixth Annual Image of the Year Contest

10x Genomics Logo

10x Genomics Launches the Next Generation of Chromium Flex to Empower Scientists to Massively Scale Single Cell Research