Date: May 16,1994, pp.16

R.A. Kahn, P. Randazzo, T. Serafini, O. Weiss, C. Rulka, J. Clark, M. Amherdt, P. Roller, L. Orci, J.E. Rothman, "The amino terminus of ADP-ribosylation factor (ARF) is a critical determinant of ARF activities and is a potent and specific inhibitor of protein transport," Journal of Biological Chemistry, 267:13039-46, 1992.

Richard A. Kahn (Laboratory of Biological Chemistry, National Cancer Institute, Bethesda, Md.): "Identified in 1980 as a factor required for the efficient ADP-ribosylation of the stimulatory, regulatory component of adenylate cyclase, Gs, ADP-ribosylation factor (ARF) remained a curiosity. By the late 1980s evidence accumulated that ARF proteins were involved in the regulation of protein traffic, though details were lacking. The lack of a neutralizing antibody and difficulty in obtaining subcellular fractions devoid of ARF made it difficult to define specific role(s) for ARF proteins using biochemical assays. "Our study led to the identification of a...

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