T.A. Steitz, "Structural studies of protein-nucleic acid interaction: the sources of sequence-specific binding," Quarterly Reviews of Biophysics, 23:205-80, 1990.

Thomas A. Steitz (Howard Hughes Medical Institute, Yale University): "The explosion of information on the structural basis of DNA and RNA recognition by proteins has been made possible in part by the ability of structural biologists to obtain large quantities of normally rare proteins and nucleic acids through cloning and chemical synthesis. Furthermore, major advances in X-ray crystallography and NMR have greatly reduced the time required to determine a structure. This article reviews all of the structural work in this field during the 1980s and discusses the structural principles of protein-nucleic acid interaction that have emerged from these studies. The structures described have become paradigms for many areas of active research in molecular and develop- mental biology, including the regulation of gene expression.

"This review has been widely cited because it...

Interested in reading more?

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?