M. Palacios, R.G. Knowles, R.M.J. Palmer, S. Moncada, "Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands," Biochemical and Biophysical Research Communications, 165:802-09, 1989.

Miriam Palacios (Wellcome Research Laboratories, Kent, England): "The discovery of the formation of nitric oxide (NO) from L-arginine by vascular endothelium, and the discovery of the role of NO as the endogenous stimulator of soluble guanylate cyclase (Biochemical Pharmacology, 38:1709-15, 1989), led to the search for this pathway in other cells and tissues. In the brain, we discovered the NO synthase and found its activity to be dependent on the free Ca2+ concentration (PNAS, 86:5159-62, 1989).

"We decided to look for the L-arginine:NO pathway in adrenal gland tissue, and found NO synthase in both the cortex and in the medulla. The enzyme was NADPH- and Ca2+-dependent, as in brain tissue. NO, acting as a transduction mechanism for the stimulation of the soluble guanylate...

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