Edited by: Eugene Russo and Steve Bunk
S.F. Altschul, T.L. Madden, A.A. Schäffer, J.H. Zhang, Z. Zhang, W. Miller, D.J. Lipman, "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs," Nucleic Acids Research, 25:3389-3402, 1997. (Cited in more than 500 papers since publication)

David Lipman, Stephen Altschul, Alejandro Schäffer, and Tom Madden
Comments by Stephen Altschul, senior investigator, National Center for Biotechnology Research, Bethesda, Md.

Tools of the trade have become increasingly important in the field of molecular biology, and few if any tools have proven more important than a sequence database search program called BLAST (Basic Local Alignment Search Tool). One of several programs used by researchers to search for similarities between newly uncovered DNA or protein sequences and those previously discovered, BLAST has the distinct advantages of being quick and easy to use. It also has capabilities that allow the program to pick...

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