Books etc.

Breast cancer's genetic profile calls the cancer stem cell hypothesis into question.

Researchers unlock a treasure trove of information about how cells sense and respond to DNA damage.

A snapshot of the adrenaline target opens the door to more high-resolution, 3-D crystal structures.

Generating the most complete evolutionary tree for mammals sparks debate and discovery.

Uncovering genomic instructions for how DNA is packaged reveals a new dimension of the genetic code.

Identifying a key protein behind ALS redirects the fight against the disease.

The discovery that blocking an inhibitory immune receptor restores T cell function in HIV sheds light on immune dysfunction.

Two yeast studies begin to identify protein interactions on a genome-wide scale.

Investigators put deletions on the map of human genetic variation.

Uncovering the molecular identity of a strange cellular channel triggers a rush of discoveries in calcium regulation.

Investigators identify key players that regulate self-renewal and differentiation in stem cell research.

Two structures of the ribosome ignite debate and discovery in structural biology.

Can microRNAs help diagnose, classify, and stage human cancers?

The paper: A. Birmingham et al., "3' UTR seed matches, but not overall identity, are associated with RNAi off-targets," Nat Methods, 3:199—204, 2006. (Cited in 94 papers) The finding: In 2006, Devin Leake and colleagues at Dharmacon Research wanted to determine the accuracy of current algorithms for predicting siRNA mismatch events used in silencing. To do t

Credit: © Zephyr / Photo Researchers, Inc." /> Credit: © Zephyr / Photo Researchers, Inc. The paper: K. O'Reilly et al., "mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt," Cancer Res, 66:1500—8, 2006. (Cited in 95 papers) The finding: It's known that rapamycin inhibits lymphoma growth but not solid tumor growth. Rapamycin activates Akt — an en

Credit: left: Jim Dowdalls / Photo Researchers, Inc." /> Credit: left: Jim Dowdalls / Photo Researchers, Inc. The paper: N. Houstis et al., "Reactive oxygen species have a causal role in multiple forms of insulin resistance," Nature, 440:944—8, 2006. (Cited in 109 papers) The finding: Evan Rosen, from Beth Israel Deaconess Medical Center in Boston, and other colleagues tested whether a common mechanism

Credit: Alfred Pasieka / Photo Researchers, Inc." /> Credit: Alfred Pasieka / Photo Researchers, Inc. The paper: R.B. Jones et al., "A quantitative protein interaction network for the ErbB receptors using protein microarrays," Nature, 439:168–74, 2006. (Cited in 98 papers) The finding: Gavin MacBeath's team at Harvard University wanted to find the proteins that get recruited to receptors in the first step of epidermal growth factor

The paper: D. Huson, D. Bryant, "Application of phylogenetic networks in evolutionary studies," Mol Biol Evol, 23:254-67, 2006. (Cited in 120 papers) The gist: In this review paper, Daniel Huson, a bioinformatician at the University of Tübingen, Germany, and David Bryant, from the University of Auckland, explained the rationale of using web-like phylogenetic networks instead of traditional trees to represe

Even healthy cells require this catabolic process.

Even healthy cells require this catabolic process.