This paper reports that the NS2-3 protease of hepatitis C virus is a cysteine protease with a novel fold, and that the active site is located at the interface of a dimer. The results suggest that dimerization (or NS2 concentration) may be a regulatory mechanism in the auto-processing of the viral polyprotein.
Columbia University, USA
This fascinating study identifies selective degradation of mRNAs encoding proteins targeted to the endoplasmic reticulum (ER) as a novel, fast component of the unfolded protein response (UPR).
Peter Van Endert
National Institute of Health and Medical Rresearch, France