Papers to Watch

M.N. Alder et al., "Diversity and function of adaptive immune receptors in a jawless vertebrate," Science, 310:1970-3, Dec. 23, 2005.A computational analysis indicates that agnathans [jawless fishes] have the potential to generate from 1014 to 1017 different variable lymphocyte receptor (VLR) genes through a process of somatic rearrangement, a level of diversity comparable to that of mammalian antibodies.John JaenikeUniversity of Rochester, NYN.M. Alto et al., "Identification

The Scientist Staff
Apr 1, 2006

M.N. Alder et al., "Diversity and function of adaptive immune receptors in a jawless vertebrate," Science, 310:1970-3, Dec. 23, 2005.

A computational analysis indicates that agnathans [jawless fishes] have the potential to generate from 1014 to 1017 different variable lymphocyte receptor (VLR) genes through a process of somatic rearrangement, a level of diversity comparable to that of mammalian antibodies.

John Jaenike
University of Rochester, NY

N.M. Alto et al., "Identification of a bacterial type III Effector family with G protein mimicry functions," Cell, 124:133-45, Jan 13 2006.

This study reports that type III effectors sharing a WxxxE motif act as Rho GTPase functional mimics. Although none of these effectors show sequence homology with GTPases, the EPEC Map protein induces Cdc42-like actin rearrangements, whereas the Shigella IpgB1 and IpgB2 effectors act as the Rac and the Rho GTPases, respectively.

Guy Tran Van Nhieu
Institut Pasteur, France

F.J. AdriÁn et...