K.K. Farh et al., "The Widespread Impact of Mammalian microRNAs on mRNA repression and evolution," Science, 310:1817-21, Dec. 16, 2005.
Expression of mRNA carrying the conserved 7 nt sites matching microRNAs can be strong at developmental stages before microRNA expression but is reduced at a later stage. Genes preferentially expressed at the same time and place as microRNAs have evolved to avoid sites matching the miRNAs by adopting non-conserved sites.
Max Planck Institute for Experimental Medicine,
W. Zhai et al., "In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets," Cell, 123:1241-53, Dec. 29, 2005.
This study is interesting as it provides a mechanistic basis for the gain-of-function mutation of the huntingtin (htt) protein responsible for the neurodegenerative Huntington Disease... The htt protein represses Sp1-dependent transcription by specifically targeting several components of the transcription complex including Sp1, TFIID and TFIIF.
Weizmann Institute of Science, Israel
S. Berger et al., "Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity," Proc Natl Acad Sci, 103:195-200, Jan. 3, 2006.
Assigning central functions to the mineralocorticoid receptor (MR), the baby sister of the glucocorticoid receptor, has been fraught with difficulties, but this fascinating paper demonstrates its role in learning, perseverance, stereotypy and novelty-induced hyperactivity.
University of Edinburgh,
Papers were selected from multiple disciplines from the Faculty of 1000, a web-based literature awareness tool (www.f1000biology.com).