Predicting Nucleosome Position

Research suggests a 'code' at work

The Scientist Staff
Oct 1, 2006

A group including Jonathan Widom at Northwestern University and Eran Segal of the Weizman Institute used sophisticated computer modeling along with experimental approaches to uncover DNA-encoded rules guiding nucleosome position.1 The verdict: several dinucleotide sequences, because of their inherent bendability, can be used to predict roughly 50% of nucleotide positions. The work, may lead to better prediction of nucleosome binding and may influence such things as transgene design. Bradley Bernstein, a Faculty of 1000 member and assistant professor at Massachusetts General Hospital calls it an "impressive analysis." He adds "The paper identified interesting correlations that are likely to reflect causal relationships."

"It suggests that the positioning of nucleosomes is in some cases deliberate and functional. So you regulate accessibility to DNA in a very precise way and you can then control whether transcription factors have access and whether a gene can be activated and so on?. I think the...

References

1. E. Segal et al., "A genomic code for nucleosome positioning," Nature, 442:772?8, Aug. 17, 2006.

Interested in reading more?

The Scientist ARCHIVED CONTENT

ACCESS MORE THAN 30,000 ARTICLES ACROSS MANY TOPICS AND DISCIPLINES

Become a Member of

Receive full access to more than 35 years of archived stories, digital editions of The Scientist Magazine, and much more!
Already a member?