Bop controls ventricle formation

Defects in cardiomyocyte differentiation and cardiac morphogenesis cause heart malformations affecting almost one in every 100 children, but the mechanisms that regulate such events remain largely unknown. In April 1 online Nature Genetics, Paul Gottlieb and colleagues from University of Texas at Austin, US, show that Bop encodes a muscle-restricted protein that is essential for cardiac differentiation and morphogenesis (Nat Genet 2002, DOI: 10.1038/ng866).

Gottlieb et al. used a modified subtractive hybridization approach and identified early cardiac-specific genes in chick and murine embryos. They observed that Bop was expressed specifically in cardiac and skeletal muscle precursors and in cardiomyocytes throughout organ development, beginning before cardiac differentiation. The protein m-Bop can interact with histone deacetylases and can function as a transcriptional repressor.

They also showed that targeted deletion of Bop in mice disrupted maturation of ventricular cardiomyocytes and interfered with formation of the right ventricle. In addition, normal expression of Hand2, ...