These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool
A. O'Doherty et al., "An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes,"
This is the first study to show that a human chromosome can be introduced into a mouse's germline and transmitted to successive generations. The authors introduced a copy of human chromosome 21. The mice carrying the human chromosome developed cardiac and other morphological abnormalities consistent with Down syndrome. This mouse now provides a potentially very useful model.
K.Y. Wu et al., "Local translation of RhoA regulates growth cone collapse,"
This is the first study to show that Semaphorin 3A-dependent signaling triggers local translation of the small GTPase RhoA at the growth cone leading to growth cone collapse,...