These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool
A.J. Dupuy et al., "Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system,"
This paper describes a modification of the Sleeping Beauty fish transposon which allows it to be used for efficient mutagenesis screens in mice. The authors provide proof-of-principle for the usefulness of the transposon (which can be targeted to any tissue) by the identification of multiple cancer genes.
J. Liou et al., "STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx,"
The mechanisms controlling store-operated calcium entry have been a long-standing mystery in calcium signaling. As in a study published just weeks earlier,1 these authors use an RNAi-based screen...