These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool
J.F. Roeth et al., "HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail."
This study defines a novel pathway by which immune evasion protein Nef of HIV-1 traffics MHC-I proteins in T cells from the trans-Golgi network (TGN) to the lysosome for degradation. Indeed, the authors show that Nef accomplishes this by stabilizing a physical association between MHC-I and adaptor protein AP-1, a cellular protein complex implicated in TGN to endolysosomal pathways.
- Ted Hansen
D.E. Martin et al., "TOR regulates ribosomal protein gene expression via PKA and the forkhead transcription factor FHL1,"
Regulation of ribosomal biosynthesis in response to environmental cues is demonstrated here to...