Courtesy of Mike Sexton
These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool
L. Li et al., "A small molecule Smac mimic potentiates TRAIL- and TNFα-mediated cell death,"
This is the first study in which a true Smac mimetic was synthesized to antagonize the inhibitor-of-apoptosis (IAP) proteins. … Importantly, these compounds synergize with TNFα and TRAIL [tumor necrosis factor-related apoptosis-inducing ligand] to potently induce caspase activation and cell death in a human glioblastoma cell line that is known to be resistant to DNA-damage-induced apoptosis.
N. Gilbert et al., "Chromatin architecture of the human genome; gene-rich domains are enriched in open chromatin fibers,"
This paper redefines our understanding of chromosome cytology by using biophysical and genomic methods to show that open chromatin is correlated with high...