Interdisciplinary Research

These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.O.O. Glebov et al., "Lipid raft proteins have a random distribution during localized activation of the T-cell receptor," Nat Cell Biol, 6:238–43, March 2004.This study ... challenges the view that lipid rafts exist as large and stable physical structures with functional roles, at least in T cells. Using FRET [fluorescence resonance energy transfe

The Scientist Staff
Aug 1, 2004
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These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.

O.O. Glebov et al., "Lipid raft proteins have a random distribution during localized activation of the T-cell receptor," Nat Cell Biol, 6:238–43, March 2004.

This study ... challenges the view that lipid rafts exist as large and stable physical structures with functional roles, at least in T cells. Using FRET [fluorescence resonance energy transfer] analysis, they show that contrary to existing data, lipid rafts may not have a role in the activation of T cells. The question is, what techniques will satisfy the stringent requirements for proof that lipid rafts exist and that they are important for compartmentalizing cell signaling?

- Emanuela Handman, The Walter and Eliza Hall Institute, Australia

J.A. Martens et al., "Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene," Nature, 429:571–4, June 3,...