These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool
G. Hutvágner et al., "Sequence-specific inhibition of small RNA function,"
Hutvágner et al. have shown that 2'-O-methyl oligonucleotides stoichiometrically and irreversibly inhibit the activity of [microRNAs and small interfering RNAs], paving the way for rapid evaluation of their in vivo functions. Further, they use a 2'-O-methyl oligonucleotide targeted against the
X.M. Sun et al., "Caspase activation inhibits proteasome function during apoptosis,"
This paper reports a novel finding that the proteasome is inactivated by caspases at an early stage of apoptosis, which provides feed-forward amplification of apoptotic signals....