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Interdisciplinary Research

These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.B. Van den Berg et al., "X-ray structure of a protein-conducting channel," Nature, 427:36–44, Jan. 1, 2004.The first crystal structure of a protein translocation channel demonstrates the principle according to which proteins are funneled across membranes. The pore has an hourglass shape with a "plug" in the middle that probably swings out of the

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These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.

B. Van den Berg et al., "X-ray structure of a protein-conducting channel," Nature, 427:36–44, Jan. 1, 2004.

The first crystal structure of a protein translocation channel demonstrates the principle according to which proteins are funneled across membranes. The pore has an hourglass shape with a "plug" in the middle that probably swings out of the way when a protein is transported across.

- Manfred Schliwa, University of Munich

A. Zeytun et al., "Fluorobodies combine GFP fluorescence with the binding characteristics of antibodies," Nat Biotechnol, 21:1473–9, December 2003.

Diverse, antibody-derived binding loops were inserted into four surface loops of a modified form of GFP, creating a library of potential binding agents that was screened successfully by phage display against a number of protein targets. High-specificity and high-affinity fluorescent binding proteins...

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