© 2004 AACR
Bacterially induced gut cancers may solidify the role of oxidative stress in tumorigenesis. Medical oncologist Fong-Fong Chu and colleagues at City of Hope's Beckman Research Institute, Duarte, Calif., found that mice missing the glutathione peroxi-dase genes
Both genes protect organisms from oxidative stress, strengthening the belief, says Chu, that such stress can lead to cancer by hastening tumorigenesis. Cancer did not develop in double-knockout mice kept in a sterile environment or in mice with at least one wild-type allele. Chu likens this to inflammatory bowel disease (IBD) models, in which mice, if kept germ-free, do not exhibit disease symptoms.