Y. Ionov, M.A. Peinado, S. Malk-hosyan, D. Shibata, M. Perucho, "Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis," Nature, 363:558-61, 1993. (Cited in 108 publications through December 1994)

Comments by Manuel Perucho,California Institute of Biological Research

This paper represents the seminal discovery by a research team from the California Institute of Biological Research in La Jolla of an instability in simple repeated sequences of DNA. The finding led to a torrent of other articles in the area of cancer mutagenesis and DNA repair.

During the course of their investigations on colorectal cancers, the authors discovered a group of tumors, with distinctive phenotypic and genotypic features, that were consistently characterized by the deletion of sequences of DNA from the genes. "Although the hypothesis of 'cancer as a mutator phenotype' was postulated more than 20 years ago, there was no precedent for our finding that...

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