Menu

Capsule Reviews

Junk DNA, Cuckoo, Sapiens, and Cool

Apr 1, 2015
Bob Grant

Junk DNA: A Journey Through the Dark Matter of the Genome

Nessa Carey
Columbia University Press, March 2015

Can we please stop calling non-protein–coding DNA “junk?” We’ve had more than a decade—since researchers first sequenced the human genome in 2001—to come to grips with the fact that 98 percent of our DNA doesn’t get translated directly into proteins. And in the intervening years, what was initially considered perplexingly abundant detritus has evolved into a wondrous genomic landscape that hasn’t disappointed intrepid explorers. Imperial College London molecular biologist and author Nessa Carey details this transformation and the progress science has made in her latest book, Junk DNA.

Carey examines the importance of noncoding DNA, from its role in controlling gene expression to the ways in which it influences RNA behavior, disease progression, and sex determination. Although we can now be sure that 98 percent of the human genome is anything but junk, researchers are only just beginning to fully appreciate the complex influence of all that once-maligned genomic material.

Junk DNA serves as a nice primer for the still-uninitiated, but here’s to hoping that continued research, and the emerging view that genomes behave like networks rather than a string of isolated genes, soon relegates the J-word to the junk pile of science history.

Cuckoo: Cheating by Nature

Nick Davies
Bloomsbury, April 2015

Cuckoos are masters of the art of deception. The medium-size, grayish birds have evolved a reproductive strategy called brood parasitism, in which they lay their eggs in the nests of other bird species, duping those hapless parents into rearing cuckoo young. Although there are other brood parasites among birds, fish, and insects, behavioral ecologist Nick Davies has made the cuckoo the lens through which he views the fascinating adaptation.

In Cuckoo, he relays the history of how science has viewed the behavior—from early observers, who struggled to fathom why the Creator made an animal with so little affection for its own offspring, to Charles Darwin, who reasoned that the interplay between cuckoo and host bird species reflected the same evolutionary arms race he’d noted between predator and prey.

Davies shares insights into his years of research on the specifics of how the cuckoo evolved brood parasitism. His obvious passion for observing cuckoos, their host birds, and the behavioral and physical traits that make them nature’s perfect cheat is liable to spark similar stirrings in aspiring naturalists who read this book.

Sapiens: A Brief History of Humankind

Yuval Noah Harari
Harper, February 2015

Human beings are the most destructive force this planet has ever seen. We change the climate, extirpate entire species, and transform ecosystems. But just how has our species come to dominate the Earth? Such is the weighty question tackled by historian Yuval Harari in his latest book, the international best-seller Sapiens: A Brief History of Humankind. “The most likely answer is the very thing that makes the debate possible,” he writes. “Homo sapiens conquered the world thanks above all to its unique language.”

And with language, Sapiens (as Harari refers to the species in the book) has created powerful myths about gods, money, politics, and human rights. These myths, when codified and shared, can draw together multitudes of individuals into cohesive groups. And in numbers, there is strength.

Harari recounts the meteoric rise of our species in light of the advantages bestowed upon us by our supple and descriptive language. But the attribute that made us so powerful could be our undoing. The author decries the seeming aimlessness with which Sapiens wields its unique skill set. “We are more powerful than ever before, but have very little idea what to do with all that power,” he writes. “We are consequently wreaking havoc on our fellow animals and on the surrounding ecosystem, seeking little more than our own comfort and amusement, yet never finding satisfaction."

Cool: How the Brain’s Hidden Quest for Cool Drives Our Economy and Shapes Our World

Steven Quartz and Anette Asp
Farrar, Straus and Giroux, April 2015

Fads may come and go, trends fluctuate, but cool is always in style. Even the word, likely co-opted to mean something hip or au courant around the late 19th century, retains its meaning among toddlers and tweens, the middle-aged and octogenarians. But why are we so universally attracted to things that are cool? The answer may lie deep in our brains, argue cognitive scientist Steven Quartz and political scientist Anette Asp in Cool.

The authors suggest that the brain’s cool circuits, which probably involve the medial prefrontal cortex and the striatum, likely drive the consumerism that so dominates myriad human cultures. Cool, in fact, is intimately related to our desire to possess, Quartz and Asp write. “Cool turns out to be a strange kind of economic value that our brains see in products that enhance our social image.”

The evidence for their model comes from studies involving functional magnetic resonance imaging (fMRI)—not the most rigorous of neuroscientific techniques—but they make a compelling case, in a series of consumer scenarios, that our modern-day spending habits reach back deep into our evolutionarily enhanced drive to be socially accepted.

February 2019

Big Storms Brewing

Can forests weather more major hurricanes?

Marketplace

Sponsored Product Updates

Bio-Rad Releases First FDA-Cleared Digital PCR System and Test for Monitoring Chronic Myeloid Leukemia Treatment Response
Bio-Rad Releases First FDA-Cleared Digital PCR System and Test for Monitoring Chronic Myeloid Leukemia Treatment Response
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a global leader of life science research and clinical diagnostic products, today announced that its QXDx AutoDG ddPCR System, which uses Bio-Rad’s Droplet Digital PCR technology, and the QXDx BCR-ABL %IS Kit are the industry’s first digital PCR products to receive U.S. Food and Drug Administration (FDA) clearance. Used together, Bio-Rad’s system and kit can precisely and reproducibly monitor molecular response to treatment in patients with chronic myeloid leukemia (CML).
Bio-Rad Showcases New Automation Features of its ZE5 Cell Analyzer at SLAS 2019
Bio-Rad Showcases New Automation Features of its ZE5 Cell Analyzer at SLAS 2019
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb) today showcases new automation features of its ZE5 Cell Analyzer during the Society for Laboratory Automation and Screening 2019 International Conference and Exhibition (SLAS) in Washington, D.C., February 2–6. These capabilities enable the ZE5 to be used for high-throughput flow cytometry in biomarker discovery and phenotypic screening.
Andrew Alliance and Sartorius Collaborate to Provide Software-Connected Pipettes for Life Science Research
Andrew Alliance and Sartorius Collaborate to Provide Software-Connected Pipettes for Life Science Research
Researchers to benefit from an innovative software-connected pipetting system, bringing improved reproducibility and traceability of experiments to life-science laboratories.
Corning Life Sciences to Feature 3D Cell Culture Technologies at SLAS 2019
Corning Life Sciences to Feature 3D Cell Culture Technologies at SLAS 2019
Corning Incorporated (NYSE: GLW) will showcase advanced 3D cell culture technologies and workflow solutions for spheroids, organoids, tissue models, and applications including ADME/toxicology at the Society for Laboratory Automation and Screening (SLAS) conference, Feb. 2-6 in Washington, D.C.