J.W. Harper, G.R. Adami, N. Wei, K. Keyomarsi, S.J. Elledge, "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases," Cell, 75:805-16, 1993. (Cited in nearly 500 publications through September 1995)

Comments by Stephen J. Elledge and J. Wade Harper, Baylor College of Medicine

"This paper describes the identification and characterization of the first human gene encoding a protein- p21Cip1-which functions to negatively regulate Cdks controlling cell-cycle entry," remarks Stephen Elledge, a professor of biochemistry at the Baylor College of Medicine and an investigator in the Howard Hughes Medical Institute there.

"Specific kinases called Cdk2 and Cdk4 are believed to play a critical role in helping a cell decide whether or not to enter into the cell cycle-the process in which a cell duplicates its DNA and organelles in order to form two new cells," explains Wade Harper, an associate professor of biochemistry at Baylor. "In...

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