Hot Papers Cell Biology Date: January 24, 1994, pp.16

H.Y. Lin, X.-F. Wang, E. Ng-Eaton, R.A. Weinberg, H.F. Lodish, "Expression cloning of the TGF-b type II receptor, a functional transmembrane serine/threonine kinase," Cell, 68:775-85, 1992.

Herbert Y. Lin (Netherlands Institute for Developmental Biology, Utrecht): "Transforming growth factor-b1 (TGF-b1) was initially identified about a decade ago as a prototypic negative growth factor, arresting cell growth at the G1 to S transition of the cell cycle. More than 20 other related members of this TGF-b superfamily of ligands have now been described. They appear to play important roles in many areas of biology, including development, embryogenesis, and morphogenesis, as well as in cell growth. Understanding how TGF-bs achieve their potent effects would greatly enhance our understanding of these processes and may provide insights into diseases such as cancer.

"In our work we describe the expression cloning of the type II TGF-b receptor...

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