Thomas Chittenden (Immunogen Inc., Cambridge, Mass.): "This work was done in the lab of David M. Livingston at the Dana- Farber Cancer Institute in Boston. The retinoblastoma protein (Rb) belongs to a class of growth regulatory proteins, termed tumor suppressors, which function to prevent tumorigenesis. Livingston's laboratory has been interested in understanding, at a molecular level, how Rb negatively regulates cell growth. In 1991 several groups, including our own, demonstrated that Rb forms a complex with the cellular transcription factor E2F. E2F contributes to the cell cycle-dependent transcription of a multitude of genes involved in DNA synthesis and cell proliferation.
"This work is an effort to understand how the activity of E2F is coordinated with...
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