K.W. Wood, C. Sarnecki, T.M. Roberts, J. Blenis, "ras mediates nerve growth factor receptor modulation of three signal- transducing protein kinases: MAP kinase, Raf-1, and RSK," Cell, 68:1041-50, 1992.

Kenneth W. Wood (Dana-Farber Cancer Institute, Boston): "RAS plays a central role in receptor tyrosine kinase (RTK)-stimulated signaling pathways, including those stimulated by nerve growth factor (NGF).

"This paper shows that RAS functions to regulate a cascade of serine/threonine kinases, which plays an important role in promoting cell growth, or, as with NGF, cell differentiation. This is particularly significant for Raf-1, because although genetic data had suggested that Raf-1 functions downstream of RAS, biochemical findings had suggested that Raf-1 could be regulated, in some cases, by receptor-mediated tyrosine phosphorylation. We provide biochemical data to support a pathway in which intermediates, including RAS, function to regulate serine/threonine phosphorylation and activation of Raf-1.

"Since a role for RAS in activation of this cascade...

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