Q.-w. Xie, H.J. Cho, J. Calaycay, et al., "Cloning and characterization of inducible nitric oxide synthase from mouse macrophages," Science, 256:225-8, 1992.

Carl Nathan (Division of Hematology-Oncology, Cornell University Medical College, New York): "In 1992, Science touted nitric oxide (NO) as `the molecule of the year.' Many articles contributed to this sobriquet. Among them, the most frequently cited has been this paper, produced in a collaboration with Merck Sharpe & Dohme Research Laboratories, Rahway, N.J., and the Beckman Research Institute of the City of Hope, Duarte, Calif.

"The impact of this study was twofold. First, it clearly established that there is more than one form of NO synthase (NOS), since the inducible enzyme from cytotoxic macrophages (iNOS) differed extensively from the constitutive isoform in the nervous system. The evidence was definitive, consisting of not only the cDNA sequence but also the amino acid sequence of the macrophage protein determined from...

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