M.W. Radomski, F.M.J. Palmer, S. Moncada, "Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells," Proceedings of the National Academy of Sciences, 87:10043-47, 1990.

Marek Radomski (The Wellcome Research Laboratories, Beckenham, Kent, United Kingdom): "This work is part of a developing project that started in our laboratory in 1987-88 with the finding that nitric oxide (NO) is formed from L-arginine by a constitutive NO synthase in the vascular endothelium. Nitric oxide, which is the transduction mechanism for the soluble guanylate cyclase, is now known to be synthesized by many cells, including neurons, cells of the adrenal gland, and platelets. Nitric oxide is also generated by an inducible NO synthase that is expressed in macrophages and other cells by immunological stimuli, including bacterial endotoxin and cytokines (for review, see Moncada, et al., Pharmacological Reviews, 43:109, 1991).

"The rationale for the present experiments...

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