H.R.B. Pelham, "Control of protein exit from the endoplasmic reticulum," Annual Review of Cell Biology, 5, 1-23, 1989.

Hugh Pelham (Medical Research Council Laboratory of Molecular Biology, Cambridge, U.K.): "There has been a lot of interest in recent years in the `sorting problem'--the question of how proteins find their correct location in cells. This is a particularly significant problem in the secretory pathway, where proteins that all start out in the endoplasmic reticulum (ER) are transported to different destinations. Recently, it has become clear that there are several abundant soluble proteins that reside in the ER, contain a particularly simple sorting signal (a C-terminal tetrapeptide), and are kept in place by a system that retrieves them from a post-ER compartment.

"My review is one of the first to cover this new sorting system in detail, and thus is a convenient citation. Its relative popularity probably reflects the wave of interest...

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