A.B. Pardee, "G1 events and regulation of cell proliferation," Science, 246, 603-8, 3 November 1989.
Arthur Pardee (Dana-Farber Cancer Institute, Boston): "This review summarizes background concepts and facts that led to the recent explosive interest in the mechanisms of cell proliferation [The Scientist, Dec. 10, 1990, page 15]. Maturation of this subject was recognized by publication of six articles in Science, of which this was one. Decades of cell biology had established principles; now, molecular biology allows in-depth analysis. Examples of the genetic and molecular events that are involved and are of great current excitement include cdc2 kinases, cyclins, p53, and the retinoblastoma gene product.
"The main concept is that proliferation of postnatal cells is regulated by extracellular factors. These factors act prior to the onset of DNA duplication; that is, they act upon cells in the G0 and the G1 phase of the cycle. Extracellular factors set in motion...
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