Medical Products Department
E.I. Du Pont de Nemours & Co.
Wilmington, Del.

" Rather than using triple-helix formation and DNA-binding proteins, a new approach is discussed that can sequence specifically cleaved supercoiled double-stranded DNAs by a hybrid nuclease utilizing D-loop formation. This design technology should facilitate the manipulation and mapping of genetic DNA.

D.R. Corey, D. Pei, P.G. Schulz, "Sequence-selective hydrolysis of duplex DNA by an oligonucleotide-irected nuclease," Journal of the American Chemical Society, 111, 8523-5, 25 October 1989. (University of California, Berkeley)

" A highly efficient and diastereoselective procedure for the preparation of substituted imines from imines using organometallic agents has been reported, eliminating the problems of side effects and poor yield.

J. Yamada, H. Satô, Y. Yamamoto, "The alkylation of a-ethoxycarbamates with organo-lead, -zinc, and copper reagents. High cram selectivity and formal nonbasic alkylation of imines," Tetrahedron Letters, 30 (41),...

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