Chemistry

CHEMISTRY

BY RON MAGOLDA
Medical Products Department
E.I. DuPont de Nemnours & Co.
Wilmington, Del.

" Ortho lithiation is a major tool inorganic synthesis A recent report extends this powerful technology to include magnesium counter ions, which offer several advantages.

R.E. Eaton, C.-H. Lee, Y. Xiong, “Magnesium amide bases and amido-grignards. 1. Ortho magnesiation,” Journal of the American Chemical Society, 111, 80 16-18, 27 September 1989. (University of Chicago, Ill.)

" A new technique, permitting quantitative determination of rate-determining carbon-hydrogen bond cleavage by DNA-cleaving agents, has been reported.

J.W. Kozarich L. Worth, Jr., B.L. Frank, D.F. Christner, et al., “Sequence-specific isotope effects on the cleavage of DNA by bleomycin,” Science, 245, 1396-99, 22 September 1989. (University of Maryland, College Park, et al.)

" A cancer chemotherapeutic strategy has been proposed, which centers on the P-450 system for inhibition. This offers a number of P-450-dependent enzymatic systems...