Ron Magolida
Medical Products Department E.I. du Pont de Nemours & Co.
Wilmington, Del.

The biosynthesis and inhibition of prostacyclin and thromboxane A2 has for almost two decades attracted tremendous interest in both the biological and chemical community. A recent paper presents evidence for the biosynthesis of these important biomolecules via a cage radical mechanism.

M. Hecker, V. Ullrich, "On the mechanism of prostacyclin and thromboxane A2 biosynthesis," Journal of Biological Chemistry, 264 (1), 141-150, 5 January 1989.

" An efficient and practical intramolecular photochemical approach for the preparation of nitrogen heterocycles has been identified.

W. Xu, Y.T. Jeon, E. Hasegawa, U.C. Yoon, P.S. Mariano, "Novel electron-transfer photocyclization reactions of alpha-silyl amine alpha, beta-unsaturated ketone and ester systems," Journal of the American Chemical Society, 111 (1), 406-8, 4 January 1989.

" Three new compounds with antibiotic activity have been isolated from a plant source.

H. Jayasuriya, J.D....

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