Skip to main content

CNS neurons from neural stem cells

Neurons from the central nervous system (CNS) can regenerate, but little is known about the potential of adult neural stem cells to develop into functional nervous cells. In April 15 online Nature Neuroscience, Hong-jun Song and colleagues from the Salk Institute, La Jolla, California, show that neural stem cells derived from adult tissues retain the potential to differentiate into cells with properties similar to that of mature CNS neurons.Song et al. established an in vitro co-culture system t

Written byTudor Toma
| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00

Neurons from the central nervous system (CNS) can regenerate, but little is known about the potential of adult neural stem cells to develop into functional nervous cells. In April 15 online Nature Neuroscience, Hong-jun Song and colleagues from the Salk Institute, La Jolla, California, show that neural stem cells derived from adult tissues retain the potential to differentiate into cells with properties similar to that of mature CNS neurons.

Song et al. established an in vitro co-culture system to examine stem cells derived from adult hippocampal tissue. They observed that progeny of adult rat neural stem cells developed into electrically active neurons and integrated into neural networks with functional synaptic transmission. In addition, they also showed that functional neurogenesis from adult stem cells was possible in co-culture with astrocytes from adult and neonatal hippocampus (Nat Neurosci 2002, DOI: 10.1038/nn844).

"These results indicate that, with additional factors, adult stem cells may ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

Related articles background image
The Scientist Digest cover September 2026
September 2026

Multiplex Microscopy Becomes Easier with Encoded Antibodies

A new system that enables researchers to uniquely tag monoclonal antibodies for use in microscopy could help simplify complex imaging studies.

View this Issue
Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Alamar Biosciences logo
Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Miltenyi
Best Practices for qPCR Assay Design and Optimization

Best Practices for qPCR Assay Design and Optimization

Bio-Rad
Beyond the Basics: Strategies for Single-Cell and Spatial Transcriptomics Analysis

Beyond the Basics: Strategies for Single-Cell and Spatial Transcriptomics Analysis

bioxcell

Products

Closeup image of a multi channel pipette dispensing pink liquid into a 96-well plate.

The ASSIST PLUS pipetting robot for affordable workflow automation

Integra Logo
Single cells in suspension

Rapidly isolate primary cells and make uniform single-cell suspensions with Corning® Cell Strainers

Corning logo
Abstract image representing cell membranes linked together.

CellBrite® Steady Membrane Stain: Cell surface staining built for real-time imaging

Biotium
sino biological logo

Monod Bio Licenses AI-designed Protein Technologies to SignalChem Biotech for Custom Discovery Assays