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Animal eggs no good for cloning?

Gene expression differences suggest cloned human embryos are pluripotent but human-animal hybrids are not

Elie Dolgin
Cloned human embryos express the genes required for pluripotency, but animal-human hybrids do not, according to a study published today (Feb. 2nd) in the journal__ linkurl:Cloning and Stem Cells.;http://www.liebertonline.com/clo __The findings pave the way for isolating human embryonic stem cells from therapeutic cloning -- a landmark that has never been achieved after linkurl:Woo-suk Hwang's discredited cloning experiments;http://www.the-scientist.com/news/display/22933/ -- but call into question the utility of interspecies embryos."These eggs simply do not reprogram," lead author linkurl:Robert Lanza,;http://www.robertlanza.com/ chief scientific officer of Advanced Cell Technology in Worcester, Mass., said of the human-animal hybrid embryos. "That puts the nail on the coffin for that whole line of work."In the face of a shortfall of human egg donors, many researchers hope that by injecting human nuclei into animal eggs they will be able to obtain patient-specific human embryonic stem cells. Although this type of work is not currently funded by the US government, it...

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