Daniel Koshland, who proposed a fundamental theory of how enzymes catalyze reactions and served as editor-in-chief of Science between 1985 and 1995, died Monday after suffering a stroke. He was 87.His research in biochemistry earned him multiple awards, including the Lasker Award and the National Medal of Science. During his tenure at Science, the journal's impact factor went up from 10.9 to 21.9.
Before Koshland, Science was known as a "sleepy journal," said Joseph Goldstein, a friend of Koshland's and a Nobel Laureate at the University of Texas Southwestern Medical Center at Dallas who said he has followed Koshland's work for 30 years. According to Richard Gallagher, editor and publisher of The Scientist, who was a senior editor of immunology and infectious diseases at Science from 1992 to 1999, the standards that Koshland set for selecting papers helped raise the journal's prominence.Koshland established a weekly "space...

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