DNA repair mapped, systems-wide

Scientists use sweeping approach to generate map of interconnected cellular responses to DNA damage

Melissa Lee Phillips
May 18, 2006
Many cellular processes -- including DNA replication and repair, cell cycle control, metabolism, and stress responses -- form an integrated response to DNA damage, according to a report in this week's Science. The authors used a systems biology approach to create a map of transcriptional networks that are activated when yeast DNA is damaged."We now know an order of magnitude more pathway connections than were known before, as far as how information is transmitted through the cell in response to damage," senior author Trey Ideker of the University of California, San Diego, told The Scientist. Looking at cellular processes from a wide-angle view -- rather than the one-gene, one-protein approach of classical biology -- permits the construction of "a complete wiring diagram" of transcriptional interactions, Ideker said, which will help scientists control cellular response to DNA damage. Scientists have gathered significant data about how DNA damage is...

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