A team of Italian researchers has identified a new sex-determination gene, according to a report in Nature Genetics. Genetic analysis has implicated R-spondin1, a member of a relatively new class of mitogens, as an ovary-promoting factor, the loss of which leads to complete sex reversal - that is, to XX males. Despite the notion that female sexual development is a "default" condition, researchers have long known there must be ovary-promoting factors. However, all previous candidates have come up short because they exhibited functional redundancy, according to Robin Lovell-Badge, of the Division of Medical Genetics at MRC National Institute for Medical Research in London.The new study is "a very important piece of work," Lovell-Badge told The Scientist. "I think it will stimulate a lot of activity."Giovanna Camerino, of the University of Pavia in Italy, and colleagues used genetic analysis of a consanguineous Italian family with four XX male...
Walter Funkreviewjperkel@the-scientist.comNature Geneticshttp://www.nature.com/ng/http://www.nimr.mrc.ac.uk/devgen/lovell/http://www.unipv.it/eng/home_eng.htmlhttp://www.nuvelo.com/about/mngmnt_funk.htmlhttp://www.landesbioscience.com/journals/cc/abstract.php?id=2305
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