Researchers have unraveled the structure of the influenza A virus nucleoprotein, a development that might lead to the functional design of protein inhibitors used in antiviral therapeutics, according to a report in Nature. The crystal structure of the nucleoprotein is a trimer, with each monomer molecule shaped like a crescent. "Each molecule has a head and a body, two domains that are linked together by a single polypeptide chain that winds back and forth between them," senior author Yizhi Jane Tao of Rice University in Houston, Texas, told The Scientist. There is also a small tail at the back of the molecule that plays an important role in the oligomerization of the protein.The viral nucleoprotein has two well known functions: It provides the scaffold for the ribonucleoprotein double helix, which is the complex in which viral RNA is packaged, and it also regulates viral RNA replication through interaction...
polymerasePaul DigardThe ScientistE coliAdolfo García-SastreThe Scientistmail@the-scientist.comThe Scientisthttp://www.the-scientist.com/article/display/14353/Naturehttp://www.nature.comhttp://biochem.rice.edu/facultydetail.cfm?riceid=291The Scientisthttp://www.the-scientist.com/article/display/22852http://www.path.cam.ac.uk/pages/digardhttp://www.mssm.edu/labs/garcia-sastre/
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