Long lifespan inhibits tumors

Longevity mutations in C. elegans are unfriendly to tumor cells, contradicting research that's suggested the opposite effect

Melissa Lee Phillips
Aug 16, 2006
Mutations that lengthen a worm's lifespan also inhibit tumor growth, according to a study in this week's Science. The authors found that mutant Caenorhabditis elegans worms that live twice as long show increased cell death and decreased cell division in tumor cells. The finding is the latest in a string of phenotypes that have been linked to longevity mutants, including resistance to memory loss, muscle deterioration, and pathogenic microorganisms."I think that these longevity pathways are allowing cells to protect themselves better against damage," said senior author Cynthia Kenyon, director of the Hillblom Center for the Biology of Aging at the University of California, San Francisco. "There's something about this more stress-resistant state that seems to increase lifespan and also disadvantage a tumor," she said.Previous work in mice has shown that calorie reduction or mutations in the insulin/insulin-like growth factor-1 (IGF-1) signaling pathway confer both a...
Elixir Pharmaceuticalsother workC. elegansgld-1gld-1daf-2gld-1daf-2Wayne Van Voorhiesdaf-2daf-2The ScientistC. elegansdaf-2The Scientistknowndaf-2daf-2Thomas Johnsonshownp53another studymphillips@the-scientist.comThe Scientisthttp://www.the-scientist.com/2006/3/1/28/1/C. elegansSciencehttp://www.sciencemag.orgThe Scientisthttp://www.the-scientist.com/article/display/19519/Caenorhabditis elegansJournal of NeurosciencePM_ID: 16306402Caenorhabditis elegansThe Journals of Gerontology Series A: Biological Sciences and Medical SciencesPM_ID: 15699524C. elegans daf-2SciencePM_ID: 12817143http://wormworld.ucsf.edu/Cancer ResearchPM_ID: 9230186EndocrinologyPM_ID: 12239127http://www.elixirpharm.com/NaturePM_ID: 11780111GeneticsPM_ID: 7713420http://darwin.nmsu.edu/~molbio/mbfaculty/vanvoorhies.htmlC. elegansNaturePM_ID: 8247153http://ibgwww.colorado.edu/tj-lab/Genes and DevelopmentPM_ID: 14871929The Scientisthttp://www.the-scientist.com/1999/1/18/6/1/EMBO JournalPM_ID: 12426394

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