Malaria parasites synch with host

Plasmodium microbes that cause malaria coordinate with the internal clocks of their hosts to increase their chances of survival

Carrie Arnold
Jan 4, 2011
Plasmodium parasites responsible for deadly outbreaks of malaria synchronize their emergence and development with the circadian rhythms of their hosts to maximize their survival and spread.
Image: Sarah Reece and Sinclair Stammers
The results, published online today (January 5) in Proceedings of the Royal Society B, give clues to why circadian clocks are maintained in so many parasite species, and may hold implications for when to administer malaria treatments to infected individuals. "This study is incredibly important," said linkurl:Deborah Bell-Pedersen,;http://www.bio.tamu.edu/facmenu/faculty/Bell-PedersenD.htm a molecular biologist at Texas A&M University, who was not involved in the study. "It helps us appreciate the role of clocks in organisms, and how they provide an advantage to their growth and well-being."For years scientists have recognized the special timing of malaria infections: millions of Plasmodium parasites emerge en masse from red blood cells to cause the fever, chills, and anemia that characterize malaria. This military precision...
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Malaria parasites (Plasmodium chabaudi) in the blood
Image: Sarah Reece and Sinclair Stammers
PlasmodiumPlasmodiumPlasmodiumA.J. O'Donnell, et al., "Fitness costs of disrupting circadian rhythms in malaria parasites," Proceedings of the Royal Society B, doi:10.1098/rspb.2010.2457.



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