MHC-matched parthenogenetic embryonic stem cells created

New strategy could make cells better transplant candidates

Cathy Tran
Dec 14, 2006
Researchers have created major histocompatible complex (MHC)-matched parthenogenetic embryonic stem (pES) cells in mice that successfully engraft in an immunocompetent system, according to a report in Science. The work is a "tremendous advance," Kent Vrana at Pennsylvania State University told The Scientist. Vrana, who was not involved in the study, explained that the successful transplantation of pES cells had previously only been accomplished in immunodeficient animals. This is the first report to assess the MHC regions of pES cells, study author George Daley at the Children's Hospital Boston and Harvard Stem Cell Institute told The Scientist. Daley and his team selected for cells that contained heterozygous MHC genes to match the egg donor. MHC mismatch is a major reason for graft rejection, particularly in bone marrow transplant.The team, led by Kitai Kim at the Children's Hospital Boston and Harvard Medical School, developed embryonic stem cells from...

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