MicroRNA genes and their target sites are under Darwinian selection and continue to evolve, according to a pair of papers out this week in Nature Genetics. Nikolaus Rajewsky used genotyping data to show that predicted microRNA target sites are under negative Darwinian pressure, while Ronald Plasterk used a massively parallel sequencing approach to identify several hundred candidate microRNAs, many of which are restricted to humans, primates, or vertebrates in general. "My reaction is, this is why we put the genomes out there," said Bob Waterston, chair and professor of genome sciences at the University of Washington, who helped generate many of the genome sequences used in the Plasterk paper. "You can see these papers taking advantage of the wealth of sequence information... I find it very gratifying." "It's an advance for evolutionary biologists and systems biologists who are interested in how humans are wired," added Phillip Zamore,...
massively parallel sequencing244 novel human and 230 novel chimpanzee candidate miRNAsunder negative Darwinian pressureHapMapPerlegenjperkel@the-scientist.comThe Scientisthttp://www.the-scientist.com/article/display/15538http://www.mdc-berlin.de/englisch/about_the_mdc/public_relations/press_releases_2006/pr_2006.htm#http://www.niob.knaw.nl/researchpages/plasterk/groupleader.htmlhttp://waterston.gs.washington.edu/http://www.umassmed.edu/bmp/faculty/zamore.cfmhttp://www.454.comhttp://www.nature.com/ng/journal/vaop/ncurrent/abs/ng1914.htmlhttp://www.nature.com/ng/journal/vaop/ncurrent/abs/ng1910.htmlThe Scientist http://www.the-scientist.com/article/display/23052http://genome.perlegen.com
Interested in reading more?
Become a Member of
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!