Adult non-progenitor cells maintain the population of insulin-secreting ß cells, according to two papers published this month. The findings, produced by two independent groups led by Doug Melton at Harvard University and Jake Kushner at the University of Pennsylvania School of Medicine, contradict a popular hypothesis that ß cell regeneration relies on specialized progenitor cells.Melton's study appears in the June issue of PLoS Biology, and Kushner's paper is in the May issue of Developmental Cell. The data are very convincing, but do not exclude the possibility that a small amount of progenitor cells help regenerate ß cells, Gladys Teitelman at State University of New York, told The Scientist."If you are looking for rare cells that could participate in regeneration, it would be hard to find them," said Teitelman, who has found evidence of ß cell precursor cells in islets after toxic injury to the pancreas."So should we...
stem cellsMalcolm AlisonThe Scientistexocrine pancreas cellsdataThe ScientistThe ScientistMeltonThe Scientistproposesearchmail@the-scientist.comhttp://www.mcb.harvard.edu/Faculty/Melton.html http://www.med.upenn.edu/camb/faculty/cbp/kushner.htmlTrends Endocrinology and Metabolismhttp://www.the-scientist.com/pubmed/11042468PLoS Biologyhttp://biology.plosjournals.org/perlserv/?request=index-html&issn=1545-7885Developmental Cellhttp://www.the-scientist.com/pubmed/17488631http://www.hscbklyn.edu/anatomy/teitelman.htmlEndocrinologyhttp://www.the-scientist.com/pubmed/11606464The Scientisthttp://www.the-scientist.com/article/display/12678 http://www.icms.qmul.ac.uk/Profiles/Diabetes/Alison%20Malcolm.htmSciencehttp://www.the-scientist.com/pubmed/15564314Naturehttp://www.the-scientist.com/pubmed/15129273The Scientist http://www.the-scientist.com/article/display/22452Journal of Molecular Endocrinologyhttp://www.the-scientist.com/pubmed/10828822The Scientisthttp://www.the-scientist.com/article/display/23394
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