New gene in Alzheimer's disease

Researchers link gene for a protein involved in amyloid recycling to AD - but with dozens of genes now associated with the disease, will this one stand out from the pack?

kerry grens
Kerry Grens

Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at...

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Jan 14, 2007
A new gene, sortilin-related receptor SORL1, is joining the ranks of other genes scientists have associated with late-onset Alzheimer's disease, thanks to a report in this week's Nature Genetics. Many of the two dozen genes already linked to the disease have disappointed researchers by demonstrating inconsistent correlation across data sets, sparking debate over the significance of the latest findings. Still, some scientists are optimistic. "The main difference is the size of the study [linking SORL1 to Alzheimer's], the replication, and the diversity of the sample," Creighton Phelps, director of the Alzheimer's Disease Centers Program at the National Institute on Aging (NIA), told The Scientist. The NIA funded a portion of the study, but Phelps was not involved in the study. The project, which included teams from Columbia University, the University of Toronto, and Boston University, sampled over 6,000 participants from seven data sets and four ethnic...

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