At the dawn of the 21st century, scientists completed the first draft of the human genome and reported that human cells encode more than 20,000 proteins. But most of the protein research performed since has focused on about 2,000 proteins (mostly enzymes) that were already known and whose functions were well studied, according to an analysis published this week in Nature.
The Scientist spoke with lead author linkurl:Aled Edwards;http://www.utoronto.ca/AlEdwardsLab/al_edwards_bio.html about this apparent research bias. Edwards, a biochemist at the University of Toronto and director of SGC, a nonprofit that encourages research on proteins of medical relevance, describes why scientists appear to be stuck in their old ways and what can be done to encourage exploration into the unknown.The Scientist: What led you and your colleagues to recognize this research bias?Aled Edwards: It was really driven by a sense by our pharmaceutical partners...
TS:AE:TS:AE:TS:AE:TS:AE:A. Edwards, et al., "Too many roads not taken," Nature, 470: 163-5, 2011.
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