Retractions unsettle structural bio

Recent findings upend conclusions from five highly-cited papers

Andrea Gawrylewski
Jan 3, 2007
Scientists from the Scripps Research Institute led by Geoffrey Chang have retracted three highly-cited papers (1, 2, 3) in Science on ATP binding cassette transporters, stating that new findings by another group invalidated their proposed structure and biology of the transporters. Two more retractions will appear in upcoming issues of the Journal of Molecular Biology and Proceedings of the National Academy of Science. The retracted papers span more than five years of work."I'm not sure there's ever been a retraction of this magnitude in the field," said Kasper Locher, a researcher and professor at the Institute of Molecular Biology and Biophysics in Switzerland, and an author of a September 2006 paper in Nature that illustrated major problems with Chang et al's findings. In an interview with The Scientist, Chang said he regretted any confusion his papers may have caused. "I deeply apologize to those...