Cells containing extra copies of chromosomes exhibit slowed proliferation regardless of what chromosome is affected, according to a new study of yeast cells published in Science this week. The results may help researchers better understand and target tumor cells, which are characterized by rapid proliferation and changed chromosome numbers - a condition known as aneuploidy."One very interesting thing, which you wouldn't necessarily have expected to be the case, is this common set of phenotypes that has come out from all these different aneuploid strains," said Mike Tyers of the Samuel Lunenfeld Research Institute in Toronto, who was not involved in the study.Angleika Amon and her team found that aneuploid yeast cells suffer a suite of disadvantageous physiological traits, suggesting that it is the cell's physiological reaction to having extra chromosomes, rather than the extra chromosomes themselves, that the cause cancer cells' unchecked growth. Researchers have long postulated that extra...
may be to blameThe ScientistSteve ElledgeThe Scientistmail@the-scientist.comSciencehttp://www.sciencemag.org/
Interested in reading more?
Become a Member of
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?