Individual Golgi compartments mature, report two teams of scientists working independently, perhaps resolving a controversy that has lingered in cell biology for decades. The studies, published this week in Nature, report observations of Golgi cisternae transitioning from early (cis) to late (trans) in the yeast Saccharomyces cerevisiae, suggesting that proteins remain within a single cisterna before being secreted."How things move within the Golgi is one of the most contentious issues of membrane biology in the modern era," said Randy Schekman, professor of cell biology at the University of California, Berkeley, who was not involved with the studies. Both groups "developed the technology to visualize what happens in a membrane stack."Currently, some cell biology textbooks teach two models of Golgi maturation. One model, sometimes called the traditional model, suggests the cisternae -- membrane sacs of the secretory pathway -- don't mature. Each cisterna has a...
scientists have discoveredBenjamin GlickGolgi proteinsAkihiko NakanoVivek MalhotraThe ScientistJuhi.Yajnik@gmail.comNaturehttp://www.nature.comNaturehttp://www.nature.comThe Scientisthttp://www.the-scientist.com/article/display/15143/http://mcb.berkeley.edu/labs/schekman/Microbiological ReviewsPM_ID: 8987360http://cmp.bsd.uchicago.edu/faculty/bGlick.htmlThe Scientisthttp://www.the-scientist.com/article/display/20036/http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=4182http://www-biology.ucsd.edu/faculty/malhotra.html
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